产品描述

动物实验低压氧舱用于模拟低压氧高原环境，压力可以根据需要自行设置，最高可模拟海拔高度12000米，适用于中小型动物如犬、猴、兔、鼠等。

整个实验装置由动物舱体、真空系统、监测及控制系统构成。设备的自动化程度高，无须专人守候，可长期持续一个月运行。 

产品特点

多功能

• 实时显示海拔和氧气浓度动态变化曲线

• 多功能编程控制：可进行阶段式、周期式、循环模式控制

• 实验过程数据可保存至U盘，可在电脑读取分析

• 具备自动换气功能，符合动物饲养规范

• 提供多方位的报警功能，提醒实验人员异常状态

确保安全

• 从设计开始到最终完成测试和检查，所有实验氧舱都遵循严格的生产过程；

• 具有紧急关闭和自动排气系统，以适应各种情况。

动物舱体

• 主体采用进口亚克力加厚材质，坚固可靠，透明方便观察；

• 铝合金及不锈钢材料支撑；

• 具有脚轮脚刹设计，方便移动。

气体输送控制系统

• 高性能低噪音的真空系统，为系统提供稳定的压力；

• 具有气体缓冲器，减小甚至消除了细股急流气体对小动物的影响；

• 完善的多级空气过滤器，确保动物舱内气体不会污染实验环境。

拓展及特殊定制

• 动物生理指标监测

• 可实现的监测指标：心电图、心率、体温、血压、呼吸、血氧饱和度；

• 呼吸代谢监控功能

• 采血给药功能

• 视频监测功能

• 动物低氧跑台装置

• 低氧强迫游泳装置

• 温控功能

  ü恒温功能，温度可控制，室温-40℃；

  ü低温功能，4℃，温度可控制，室温-4℃；

• 可定制其它功能

应用领域

高原医学研究、肺水肿、脑水肿、肺动脉高压等疾病研究

型号说明

客户名单(部分)

相关文献

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591.

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics ,Volume 729,109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J]European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner,[J]European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang,Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling,[J]Biomedicine & Pharmacotherapy, Volume 156,2022,113982.

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan,Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J]Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Jing Zhang,Jian-Zhong Jiang,Jun Xu,Chen-Yu Xu,Shan Mao,Ying Shi , Wei Gu , Chun-Fang Zou , Yue-Ming Zhao , Liang Ye."Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea"[J]Annals of Vascular Surgery,Available online 2 February 2023.

[8]Zhang, C., Sun, Y., Guo, Y. et al."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J].Cell Death Discov. 9, 98 (2023).

[9]Zhang, L., Liu, X., Wei, Q. et al."Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p."[J]. Mamm Genome 34,76–89 (2023).

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[12]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J].European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065.

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982.

[14]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang"High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue."[J]. Antioxidants 2022,11, 2367.

[15]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen."[J]. bioRxiv preprint, 2023.03.23.533972.

[16]Ailin Yang, Lifei Guo, Yanfang Zhang, Chenjin Qiao, Yijin Wang, Jiaying Li, Min Wang, Jinliang Xing, Fei Li, Lele Ji, Haitao Guo, Ru Zhang,MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production,Biochimica et Biophysica Acta (BBA) - General Subjects,Volume 1867, Issue 9,2023,130413,ISSN 0304-4165.

[17]Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 …N Jia, Z Shen, S Zhao, Y Wang, C Pei, D Huang… - International 2023 - Elsevier… The rats were placed in a hypobaric hypoxia chamber (ProOx-830, Tow-Int Tech, Shanghai,China) to mimic the environment of high-altitude hypobaric hypoxic.

[18]Nan Jia, Zherui Shen, Sijing Zhao, Yilan Wang, Caixia Pei, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway,International Immunopharmacology,Volume 121,2023,110423,ISSN 1567-5769.

[19]AUTHOR=Long Yanrong, Chen Hongbin, Deng Junchao, Ning Junjie, Yang Pengbo, Qiao Lina, Cao Zhongwei ，TITLE=Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice ，JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 DOI=10.3389/fphar.2022.1039103 ，The chamber contained a continuous oxygen monitoring system (ProOX-100HE, TOW-INTTECH).

[20]Xueting Wang,Yuqi Xie,Yun Niu,Baolan Wan,Yapeng Lu, Qianqian Luo,Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348.

[21]Liu,J,Peng,S,Ye,L,Sun,Y,Zhao,Q,Wei,H, Luo, Q, He M,& Wang,G(2023)."Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization."[J].Frontiers in Cellular Neuroscience,17,1152392.doi:10.3389/fncel.2023.1152392.

[22]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism."[J].WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018.

[23]Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[24]Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[25]Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[26]Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[27]Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

参考：

高原疾病介绍

不同的海拔高度大气压和氧分压的变化对比

 *我公司可提供3Q验证，根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。

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  动物实验低压氧舱（恒温版）

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  动物实验低压氧舱（标准款）