产品描述

动物实验低压氧舱用于模拟低压氧高原环境，压力可以根据需要自行设置，最高可模拟海拔高度12000米，适用于更多的鼠笼或中小型动物如犬、猴、兔、鼠等。

整个实验装置由动物舱体、真空系统、监测及控制系统构成。设备的自动化程度高，无须专人守候，可长期持续一个月运行。 

产品描述

多功能

• 实时显示海拔和氧气浓度动态变化曲线

• 多功能编程控制：可进行阶段式、周期式、循环模式控制

• 实验过程数据可保存至U盘，可在电脑读取分析

• 具备自动换气功能，符合动物饲养规范

• 提供多方位的报警功能，提醒实验人员异常状态

确保安全

• 从设计开始到最终完成测试和检查，所有实验氧舱都遵循严格的生产过程；

• 具有紧急关闭和自动排气系统，以适应各种情况。

动物舱体

• 主体采用进口亚克力加厚材质，坚固可靠，透明方便观察；

• 铝合金及不锈钢材料支撑；

• 具有脚轮脚刹设计，方便移动。

气体输送控制系统

• 高性能低噪音的真空系统，为系统提供稳定的压力；

• 具有气体缓冲器，减小甚至消除了细股急流气体对小动物的影响；

• 完善的多级空气过滤器，确保动物舱内气体不会污染实验环境。

拓展及特殊定制

• 动物生理指标监测

• 可实现的监测指标：心电图、心率、体温、血压、呼吸、血氧饱和度；

• 呼吸代谢监控功能

• 采血给药功能

• 视频监测功能

• 动物低氧跑台装置

• 低氧强迫游泳装置

温控功能

恒温功能，温度可控制，室温-40℃；

低温功能，4℃，温度可控制，室温-4℃；

• 可定制其它功能

应用领域

高原医学研究、肺水肿、脑水肿、肺动脉高压等疾病研究

型号说明

客户名单（部分）

相关文献

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591.

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics ,Volume 729,109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J]European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu,Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner,[J]European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling,[J]Biomedicine & Pharmacotherapy, Volume 156,2022,113982.

[6]Fang Zhao，Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang，Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J]Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Jing Zhang，Jian-Zhong Jiang，Jun Xu，Chen-Yu Xu，Shan Mao,Ying Shi,Wei Gu,Chun-Fang Zou,Yue-Ming Zhao,Liang Ye."Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea"[J]Annals of Vascular Surgery, Available online 2 February 2023.

[8]Zhang, C.,Sun, Y.,Guo,Y.et al."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J].Cell Death Discov.9,98(2023).

[9]Zhang, L.,Liu,X., Wei, Q. et al."Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p."[J]. Mamm Genome 34, 76–89 (2023).

[10]Yanhong Pei a b,Lifei Huang c,Tong Wang c,Qinhan Yao a,Yanrong Sun a,Yan Zhang a,Xiaomei Yang a,Jiliang Zhai d,Lihua Qin a, Jiajia Xue c,Xing Wang c,Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES,Volume 17,March 2023,100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[12]Jun-Yu Wei,Miao-Yue Hu,Xiu-Qi Chen, Feng-Ying Lei,Jin-Shuang Wei,Jie Chen, Xuan-Kai Qin & Yuan-Han Qin."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J].European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[13]Yilan Wang,Zherui Shen,Caixia Pei,Sijing Zhao,Nan Jia, Demei Huang,Xiaomin Wang,Yongcan Wu, Shihua Shi, Yacong He,Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J].Biomedicine & Pharmacotherapy,Volume 156,2022,113982.

[14]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang"High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue."[J]. Antioxidants 2022,11, 2367.

[15]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen."[J]. bioRxiv preprint, 2023.03.23.533972.

[16]Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qianqian Luo, Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348.

[17]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H, Luo, Q, He M, & Wang, G(2023)."Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization."[J]. Frontiers in Cellular Neuroscience, 17, 1152392. doi: 10.3389/fncel.2023.1152392.

[18]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism."[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018.

[19]Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[20]Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[21]Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[22]Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[23]Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

参考研究

高原疾病介绍

不同的海拔高度大气压和氧分压的变化对比

 *我公司可提供3Q验证，根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。

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  动物实验低压氧舱（恒温版）

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  动物实验低压氧舱（标准款）