动物实验低压氧舱用于模拟低压氧高原环境，压力可以根据需要自行设置，最高可模拟海拔高度12000米，适用于更多的鼠笼或中小型动物如犬、猴、兔、鼠等。

整个实验装置由动物舱体、真空系统、监测及控制系统构成。设备的自动化程度高，无须专人守候，可长期持续一个月运行。

产品特点：

人性化操作

采用10英寸触摸屏，人性化界面设计，操作简便。

两种控制方式：自动、手动，断电可操控；具有传感器组件及机械表双重监测功能。设备自动化程序设计，无须专人守候，可长期持续运转。

实时显示海拔和氧分压动态变化曲线。

实验过程数据可导出csv格式保存到U盘中，在电脑中读取分析。

可根据客户实验需求，订制实验环境及配套其他相关实验设备。

配备动物低压专用水瓶，防止在负压环境中，水滴漏速过快。

操作安全放心 

配备自动换气功能，符合动物饲养规范。

提供多方位报警功能（温度、湿度、压力、氧浓度 上/下限），防止出现安全隐患。配备渐开手轮式舱门，降低因为误操作造成的伤害。

舱体采用透明厚亚克力材质，方便研究人员观察实验动物情况。

配备气体缓冲器，减小、甚至消除了细股急流气体对小动物的影响。

配备多级空气过滤器，确保动物舱内实验环境空气不会收到污染。

参数显示/功能全

拓展及特殊定制

动物生理指标监测

可实现的监测指标：心电图、心率、体温、血压、呼吸、血氧饱和度；

呼吸代谢监控功能

采血给药功能

视频监测功能

动物低氧跑台装置

低氧强迫游泳装置

温控功能

恒温功能，温度可控制，室温-40℃；

低温功能，4℃，温度可控制，室温-4℃；

可定制其它功能

应用领域

高原医学研究、肺水肿、脑水肿、肺动脉高压等疾病研究

型号说明

客户名单（部分）

相关文献

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina."Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling".[J]. Archives of Biochemistry and Biophysics ,Volume 729,109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J]. European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J]. Biomedicine & Pharmacotherapy,Volume 156,2022,113982.

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway".[J].Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[8]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J]. European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[9]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J]. Biomedicine & Pharmacotherapy, Volume 156,2022,113982.

[10]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang"High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue."[J]. Antioxidants 2022,11,2367.

[11]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen."[J]. bioRxiv preprint, 2023.03.23.533972.

[12]Xueting Wang,Yuqi Xie,Yun Niu,Baolan Wan, Yapeng Lu,Qianqian Luo,Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10,DOI:10.3389/fncel.2023.1189348.

[13]Liu,J,Peng,S,Ye,L,Sun,Y,Zhao, Q, Wei, H,Luo, Q, He M, & Wang, G(2023)."Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization."[J]. Frontiers in Cellular Neuroscience,17,1152392.doi: 10.3389/fncel.2023.1152392.

[14]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism."[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018.

[15]Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[16]Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[17]Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[18]Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[19]Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

参考研究

高原疾病介绍

不同的海拔高度大气压和氧分压的变化对比

*我公司可提供3Q验证，根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。 

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  动物实验低压氧舱（恒温版）

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  动物实验低压氧舱（标准款）