产品描述 

动物实验低压氧舱用于模拟低压氧高原环境，压力可以根据需要自行设置，最高可模拟海拔高度8000米，适用于中小型动物如兔、鼠等。

整个实验装置由动物舱体、真空系统、监测及控制系统构成。设备的自动化程度高，无须专人守候，可长期持续一个月运行。 

产品特点

多功能

实时显示海拔和氧气浓度动态变化曲

多功能编程控制：可进行阶段式、周期式、循环模式控制

具备自动换气功能，符合动物饲养规范

提供多方位的报警功能，提醒实验人员异常状态

确保安全

从设计开始到最终完成测试和检查，所有实验氧舱都遵循严格的生产过程；

具有紧急关闭和自动排气系统，以适应各种情况。

动物舱体

主体采用进口亚克力加厚材质，坚固可靠，透明方便观察；

铝合金及不锈钢材料支撑

应用领域

高原医学研究、肺水肿、脑水肿、肺动脉高压等疾病研究

型号说明

客户名单（部分）

相关文献

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591.

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics,Volume 729,109393.

[3]Ya peng,Lu PanpanChang,Wang wangDing,Jiang peiBian,Dan Wang,Xue tingWang,Qian qianLuo,Xiao meiWu,Li Zhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J]European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner, [J]European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling,[J]Biomedicine & Pharmacotherapy,Volume 156,2022,113982.

[6]Fang Zhao,Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J]Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Jing Zhang,Jian ZhongJiang,Jun Xu , Chen-Yu Xu,Shan Mao,Ying Shi,Wei Gu,Chun FangZou,Yue-Ming Zhao,Liang Ye.”Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea”[J]Annals of Vascular Surgery, Available online 2 February 2023.

[8]C.,Sun,Y.,Guo,Y.et al."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J].Cell Death Discov.9,98 (2023).

[9]Zhang,L.,Liu, X.,Wei, Q. et al."Arginine attenuates chronic mountain sickness in rats via micro RNA-144-5p."[J].Mamm Genome 34,76–89(2023).

[10]Yanhong Pei a b,Lifei Huang c, Tong Wang c,Qinhan Yao a,Yanrong Sun a,Yan Zhang a,Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a,Jiajia Xue c,Xing Wang c,Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES,Volume 17,March 2023,100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[12]Jun-Yu Wei, Miao-Yue Hu,Xiu-Qi Chen,Feng-Ying Lei,Jin-Shuang Wei, Jie Chen,Xuan-Kai Qin & Yuan-Han Qin."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J].European Journal of Pharmacology,Renal Failure,44:1,2056-2065.

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J]. Biomedicine & Pharmacotherapy, Volume 156,2022,113982.

[14]Yanfei Zhang,Jinyu Fang,Yingyue Dong,Huiru Ding,Quancheng Cheng, Huaicun Liu, Guoheng Xu,Weiguang Zhang"High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue."[J]. Antioxidants 2022,11,2367.

[15]Wan-ping Yang,Mei-qi Li,Jie Ding,Jia-yan Li,Gang Wu,Bao Liu,Yu-qi Gao,Guo-hua Wang,Qian-qian Luo."High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen."[J].bioRxiv preprint,2023.03.23.533972.

[16]Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[17]Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[18]Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[19]Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[20]Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

[21]Jia N, Shen Z, Zhao S, et al. Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway[J]. International Immunopharmacology, 2023, 121: 110423.

[22]Pei C, Jia N, Wang Y, et al. Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway[J]. European Journal of Pharmacology, 2023, 959: 176065.

参考：

高原疾病介绍

不同的海拔高度大气压和氧分压的变化对比

*我公司可提供3Q验证，根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。

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  动物实验低压氧舱（恒温版）

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  动物实验低压氧舱（标准款）