产品描述

动物高低压氧舱是专门为实验动物设计的一款实验氧舱，可同时用于低压氧和高压氧研究。具有手动和自动两种操作方式，可用于模拟高原环境，制作脑水肿、肺动脉高压等动物模型。

产品特点

· 采用10英寸触摸屏，操作简单

· 实时显示压力和氧气浓度动态变化曲线

· 最高可模拟10000米海拔高度，最大压力达0.15MPa

· 具备自动换气功能，符合动物饲养规范

· 动物舱体采用进口亚克力加厚耗材，坚固可靠

· 具有抽拉式动物载床，方便去放动物与清洁

· 具有气体缓冲器，减小细股急流气体对动物的影响

· 多级空气过滤器确保气体清洁，同时去除空气供应中的微粒物质、水分、油和油蒸汽

· 提供多方位的报警功能，提醒实验人员异常状态

应用领域

高原医学研究、肺水肿、脑水肿、肺动脉高压等疾病研究

型号说明

使用客户名单

相关文献

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina.Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591.

[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics,Volume 729,109393.

[3]Ya peng,Lu PanpanChang,Wang wangDing,Jiang peiBian,Dan Wang,Xue tingWang,Qian qianLuo,Xiao meiWu,Li Zhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J]European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen,Feng-Ying Lei,Jin-Shuang Wei,Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner,[J]European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi,Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling,[J]Biomedicine & Pharmacotherapy,Volume 156, 2022,113982.

[6]Fang Zhao,Yan Meng,Yue Wang,Siqi Fan,Yu Liu,Xiangfeng Zhang,Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J]Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Jing Zhang,Jian-Zhong Jiang,Jun Xu,Chen-Yu Xu,Shan Mao,Ying Shi,Wei Gu,Chun-Fang Zou,Yue-Ming Zhao,Liang Ye."Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea"[J]Annals of Vascular Surgery, Available online 2 February 2023.

[8]Zhang,C.,Sun,Y., Guo,Y. et al."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J].Cell Death Discov.9, 98 (2023).

[9]Zhang,L., Liu,X.,Wei,Q. et al."Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p."[J]. Mamm Genome 34,76–89 (2023).

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023,100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia".[J] International Journal of Pharmaceutics,2020,591.

[12]Jun-Yu Wei,Miao-Yue Hu,Xiu-Qi Chen,Feng-Ying Lei,Jin-Shuang Wei,Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J]. European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982.

[14]Yanfei Zhang,Jinyu Fang,Yingyue Dong,Huiru Ding,Quancheng Cheng,Huaicun Liu,Guoheng Xu, Weiguang Zhang"High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue."[J]. Antioxidants 2022,11,2367.

[15]Wan-ping Yang,Mei-qi Li,Jie Ding,Jia-yan Li,Gang Wu,Bao Liu,Yu-qi Gao,Guo-hua Wang,Qian-qian Luo."High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen."[J].bioRxiv preprint,2023.03.23.533972.

[16]Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qianqian Luo, Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348.

[17]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H,Luo, Q, He M, & Wang, G(2023)."Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization."[J]. Frontiers in Cellular Neuroscience,17,1152392. doi：10.3389/fncel.2023.1152392.

[18]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism."[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018.

[19]Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[20]Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[21]Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[22]Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[23]Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

参考：

高原疾病介绍

不同的海拔高度大气压和氧分压的变化对比

*我公司可提供3Q验证，根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。

• 

  动物实验低压氧舱（恒温版）

• 

  动物实验低压氧舱（标准款）