Product Description

The small animal oral and nasal exposure system is suitable for the oral and nasal administration and oral inhalation exposure experiments on mice, rats, guinea pigs and other experimental animals. The system has good air tightness and uniform exposure concentration, and is suitable for the use of liquid gas. Oral and nasal inhalation poisoning experiments of inhalable substances such as sol, dust aerosol, nanoparticle aerosol, and smoke. The system can ensure the consistency of the inhaled exposure dose of animals in the same experimental group ; realize online concentration detection of aerosols and real-time online sampling of samples; adopt a high-precision control system to ensure the uniformity and stability of exposure.

The animal exposure system can test a variety of different substances, including drugs, air pollutants, PM2.5, organic substances, industrial hygiene, agricultural chemicals, etc. It can carry out acute poisoning, chronic poisoning, low pressure, high pressure, hypoxia, hyperoxia and other gas exposure experiments.

Features

· Double-chamber Design of Exposure Tower

Experimental channel: standard 24-channel configuration, 12 channels per layer, divided into upper and lower layers. Stackable upgrades possible

Each layer is removable for easy cleaning

Material: Stainless steel

Double-chamber design, the inner chamber is a drug aerosol, and the aerosol is directly transported to the channel; the outer chamber collects the exhaled gas of the animal. Separation of inner and outer cavities to prevent re-inhalation of exhaled air by animals

· Aerosol Monitoring and Control

Comprehensive monitoring of environmental indicators and system operation indicators

Monitoring indicators: temperature, humidity, oxygen concentration, carbon dioxide concentration, pressure, drug concentration, aerosol particle size distribution (optional), etc.

· Exhaust Gas Treatment & Poisoning Chamber

It has a professional multi-stage exhaust gas treatment module, and the exhaust gas can meet the laboratory safety emission requirements after treatment.Provide poisoning chamber to ensure the safety of experimenters

· Security Alarm

Environmental indicators abnormal alarm: too low oxygen concentration, too high carbon dioxide will lead to animal death. When the set safety is exceeded, the system automatically starts an alarm. Alarm setting parameters: oxygen concentration, carbon dioxide concentration, temperature system abnormal alarm.

· Supported Infected Sample Sources

Support liquid aerosol generator, dust aerosol generator, nanoparticle aerosol generator, PM2.5 enrichment and generator, cigarette smoke generator, SO2/ozone/NO2 gas, pollen, etc.

· Applicable Animals

The small animal oral and nasal exposure system designed by TOW-Int Tech is flexible in configuration and provides animal immobilizers of different sizes. Standard with mouse, rat/guinea pig accessories, optional components for dogs, rabbits, NHP and other animals. TOW-Int Tech specializes in providing various experimental animal inhalation drug administration and exposure programs, and tailors various exposure systems according to the needs of users, including animal systemic inhalation exposure systems, animal oral and nasal inhalation exposure systems, and cell exposure systems. contamination system, etc.

Application 

Respiratory disease modeling, drug efficacy evaluation, drug safety evaluation, inhalation toxicology research, environmental safety evaluation, PM2.5 research, chemical and pesticide safety evaluation, radioactive material hazard evaluation, military medicine, aerospace medicine, etc.

Configuration

 [1]Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents.Fan Z, Zhou B, Liu Y, Sun W, Fang Y, Lu H, Chen D, Lu K, Wu X, Xiao T, Xie W, Bian Q.AAPS PharmSciTech. 2022 Jan 6;23(1):50. doi: 10.1208/s12249-021-02191-8.