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Home > PRODUCTS > Respiratory Research > Pulmonary Function Test (PFT)/ Whole-body Plethysmopraphy (WBP)

Whole-body Plethysmography System for NHP

Product model：

WBP-P

Detailed introduction:

The whole-body plethysmograph (WBP) developed by Tow-Int Tech is capable of measuring respiratory parameters of animals in co... View details >
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Detailed Introduction

Whole-body Plethysmograph (WBP) can be used to measure lung function and airway response in large full-conscious and free moving laboratory animals, smartly exempting the need of traumatic tracheotomy and anesthesia.


Product Description

Whole-body Plethysmograph (WBP) can be used to measure lung function and airway response in large full-conscious and free moving laboratory animals, smartly exempting the need of traumatic tracheotomy and anesthesia, making the experimental process simple, quick, and suitable for long-term follow-up study.


Product Features

  1.  Suitable for rabbits and canines

  2. No surgery is required and the operation is simple

  3. It can be used in the study of animal respiration in full-conscious state and long-term follow-up experiments and is suitable for preliminary drug screening

  4. It has a drug aerosol nebulization module

  5.  It comes with automatic calibration function

  6. Feeding troughs can be provided for long-term continuous monitoring

  7. Optional functions are available, for example the measurements of ECG, blood pressure, body temperature, heart rate and other vital signs, which can be combined with implantable telemetry equipment

  8. Equipped with analysis software, data can be saved in Excel or TXT format (Customization is available catering to customers' specific requirements)


Test Parameters




4-Channel Whole-body Plethysmography System for Mice(图1)










Ti: Inspiratory Time (s)

Te: Expiratory Time (s)

PIF: Peak Inspiratory Flow (ml/s)

PEF: Peak Expiratory Flow (ml/s)

Volbal:Difference between Inspiratory/Expiratory Volume

F:Flowrate (breaths per minute)

Vt: Tidal Volume（ml）

Mv: Minute Ventilation（ml）

AV: Accumulated Volume（ml）

EF50: Mid-tidal Expiratory Flow

EIP: End-inspiratory Pause (Invasive Method)

EEP: End-expiatory Pause (Invasive Method)

TR: Relax Time

PenH: Enhanced Pause

Rpef: Ratio of Time to Peak Expiratory Flow


Applications

1. Researches on various respiratory diseases, such as asthma, pulmonary fibrosis, lung injury, ARDS, lung cancer, etc.

2. Safety pharmacology: the effect of drugs on the respiratory system

3. Sleep apnea: monitor animal hypopnea, obstructive apnea, etc.

4. Environmental Toxicology: The impact of environmental pollutants on animal respiration

5. Inhalation Toxicology: Toxic effects of toxic substances on the respiratory system

6. High altitude medicine: The influence of high altitude environment on the respiratory system

7. Other occasions where respiratory parameters need to be evaluated


Configuration

Name

Model

Description

Unit

Whole-body Plethysmography System

WBP-P

For non-human primate (NHP)

Set

Whole-body Plethysmography System

WBP-T

For rabbits

Set

 




[1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

[2]李宁,李红鹏,张本炎,张柳,沈继敏,李庆云.高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制[J].中华医学杂志,2021,101(36):2893-2899.

[3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:





*Our company can provide customized services according to customers' special applications, requirements, as well as experimental services. Please kindly contact us for more information.